Thousands concurrent parallel read write accesses over tens of millions of small files is a terrible performance tuning problem for e-mail servers.
You must understand and fine tune all your infrastructure chain, following the previous articles for data storage and multipath on Debian 5.x Lenny.
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I have benchmarked various Linux filesystems using different blocksizes and workloads on an mdadm RAID 1 setup using two Western Digital 500 GB SATA 3.0 drives and a 3ware 9550XS 4-port hardware RAID card (which I had trouble getting to work initially). It's not as extensive as I would have liked, but I came across some interesting results.
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